Computer-generated illustration, based on scanning electron microscopic imagery, of Streptococcus pyogenes. Copyright holder: Jennifer Oosthuizen - Medical Illustrator. Link: https://phil.cdc.gov/Details.aspx?pid=22884.
Streptococcus pyogenes, also known as group A Streptococcus or GAS, is a bacteria responsible for a wide range of diseases such as pharyngitis, scarlet fever, strep throat and acute rheumatic fever [1, 2]. Even though the global burden of GAS is not known in detail, an estimated 500,000 deaths are caused by severe GAS infections each year, making it one of the major human pathogens .
Even though a vaccine is under development, antibiotics remain the way to treat GAS related infections and despite GAS being susceptible to penicillin, broad-spectrum antibiotics are often unnecessarily prescribed  which risk to further drive antibiotic resistance.
1928 offers the following analyses of S. pyogenes: