The 1928 Platform supports microbiologists and infection control professionals who want to take full advantage of DNA-sequencing for transmission analysis and taxonomic classification of bacteria and fungi.
HOW IT WORKS
A WGS infection control workflow with 1928
WGS is the gold standard for determining genetic relatedness. Together with the discriminatory power of WGS and the context from metadata, the 1928 platform adds an increased resolution and understanding of the transmission pathways in the hospital.
Sample Source
- Environmental
- Screening
- Clinical
Culture
- Sample isolate from any bacteria/fungi
Sequence
- Independent of sequencing platform
1928
- Confirm transmission
- Determine severity
- Contextualize transmissions by adding metadata
- Report and communicate
METHODOLOGY
Epidemiologic typing
The 1928 platform uses core genome multilocus sequence typing (cgMLST) for outbreak tracing. This method is robust and enables strong comparability between sample sets. We generate our own cgMLST schemes which consists of conserved genes that can be used to generate a “pathogen fingerprint”. By visualising the number of identical genes found in phylogenetic trees, large sample sets can be compared and groups of closely related samples can be identified as outbreaks. The method also allows for new samples to be compared to historical data previously uploaded.
HOW TO USE THE 1928 PLATFORM
Quick project start in your own lab
Upload sequencing raw data fastq-files to our cloud-based web server.
The analysis starts automatically. In a few minutes you will receive reports on your samples.
Your NGS raw data is transcribed to results, providing an understanding of both what is unique in the sample and the overall picture in between samples.
Every implementation is supported by our experts.
MONITOR AND ANALYZE
All species bioinformatics analyses
Service in the cloud for bacterial and fungal DNA sequences.
Analysis includes:
- Quality control including sample quality
- Automatic species identification
- cgMLST for the most common bacterial HAI pathogens
- SNP for all species
- Bacterial resistance and virulence markers
- Epidemiological metadata
WHAT WE OFFER
Worried about the interpretations?
We have a skilled team ready to give you all the support you need to be confident in communicating your findings. Bioinformatics and technical support include:
- Active monitoring by 1928 team to ensure a complete relevant analysis
- Hospital organization configuration for access to user accounts, units and sharing groups
- General training in the service and analysis for all users in the platform
- Assistance with technical evaluation of results
WHAT YOU GET
Boost your transmission analysis with our user-friendly platform
Reliability & Validity
All analysis pipelines are validated and benchmarked against public reference databases and in cooperation with regional and international collaborators.
Security & Privacy
ISO 27001 certification and compliance with GDPR and HIPAA ensure data and information security.
Best-in-class
1928’s analysis of WGS provides the highest discriminatory power for typing of pathogens.
Predictable Costs
Downstream analysis cost is fixed and easily predicted = improved control of cost of operations.
WHY CHOOSE THE 1928 PLATFORM?
Check out our CTO, Fredrik Dyrkell, explaining the advantages you can get
Cloud service platform for microbial analysis
1928 is a cloud-based service that analyzes resistance markers from whole-genome sequences (WGS). Our technology searches for resistance markers and performs relational analysis between samples.
From raw reads to result in minutes
You start by uploading the sample to our cloud-based platform and the analysis starts automatically. Your NGS raw data is transcribed to results, providing an understanding of both what is unique in the sample and the overall picture in between samples.
Start today
Several hospitals in Europe and the USA are already now getting value out of the 1928 service. So, if you are starting to do WGS, we will be happy to provide the analysis for you.
Get started quickly
Getting started with the 1928 Platform is easy. Our Team helps you from demo to implementation.
Ask us any questions – your answer is just a click away!
Contact 1928 Sales