The Mycobacterium tuberculosis complex is a genetically related group of Mycobacterium species that can cause tuberculosis in humans or animals.


Whole-genome sequencing (WGS)

Whole-genome sequencing (WGS) analysis refers to the process of analyzing the genetic material of the bacterium that causes tuberculosis, to gain a better understanding of its characteristics and the factors that contribute to its pathogenesis.

WGS involves investigating the genetic sequence of the M. tuberculosis complex. It can provide information on the genetic diversity of the bacterium and its susceptibility to various drugs. Overall, tuberculosis WGS analysis plays an important role in the decision support for diagnosis and treatment of tuberculosis, as well as in understanding the epidemiology and evolution of the disease.


1928 bioinformatics analyses
– a rapid way of taking the assumption out of your MBT complex

The 1928 Bioinformatics Platform contains validated and customized algorithms that process the raw data files directly from the sequencing machine. The processed MBTC data is matched to our databases of genetic markers, coding for AMR (antimicrobial resistance).

Due to streamlined and efficient bioinformatic workflows and optimized data processing – easy-to-interpret results are generated fast and delivered in the 1928 Platform.

The result will also contain species-ID and epidemiological data to enable transmission analysis.


We are here to help manage your sequencing data

Analysis includes:

  • Species prediction capability
    M. tuberculosis, M. canettii

  • cgMLST support
    M. tuberculosis, M. africanum, M. orygis, M. bovis, M. microti, M. canettii, M. caprae, M. pinnipedii, M. suricattae, M. mungi

  • Shortread analysis packages

    The following table shows which bacterial species and analyses are currently supported by the 1928 Platform. The user is advised to use the autodetect feature during file upload, which will dispatch each sample to the correct pipeline.

Pipeline Resistance markers cgMLST base reference Core genes Additional typing
MBT complex Mutations HN-321 2742 SNP

Tuberculosis, often shortened to TB, is a potentially serious bacterial infection that mainly affects the lungs but can also affect other parts of the body, such as the kidneys, spine, or brain. TB spreads through the air when an infected person coughs, sneezes, or talks. People with weakened immune systems are more vulnerable to developing active TB disease. Symptoms of TB can include coughing that lasts for more than two weeks, coughing up blood, chest pain, fatigue, fever, and night sweats.

TB can be treated with antibiotics for six to nine months, but in some cases, drug-resistant TB can occur, which requires longer and more complex treatment.

TB is a major global public health problem, causing significant morbidity and mortality worldwide. According to the World Health Organization (WHO), in 2020, there were an estimated 10 million cases of TB worldwide, with 1.4 million associated deaths. TB mortality has been declining slowly over the years, but it remains one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent.

The burden of TB is highest in low- and middle-income countries (LMIC), with 95% of TB deaths occurring in these countries. TB mortality is also higher among vulnerable populations, including people living with HIV, children under the age of 5, and people who are malnourished or have other underlying health conditions.


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