2019-11-28

White Paper: 1928D – a decision support tool for genome sequence based epidemiological investigations of S. aureus outbreaks

Image of a user working in the 1928 platform on their computer.

During the last decade, whole genome sequencing (WGS), has revolutionized biology. The fast decline in price per sequenced genome, combined with the increase in technology performance, has made WGS a viable tool for research and medicine. Fast and efficient data analysis is a prerequisite to be able to use WGS to its full potential, especially in the clinical setting. The 1928D platform from 1928 Diagnostics addresses this problem by automatically generating resistance profiles and identifying type of bacteria (genetic fingerprint).

The genetic fingerprint enables high precision outbreak tracing, leading to improved surveillance by detecting contamination and transmission of pathogens, and the resistance profiles are based on manually curated proprietary databases containing only clinically relevant genetic markers.

1928 Diagnostics develop analysis services according to strict quality procedures and new features and products go through extensive validation before released on the platform. Apart from the analysis service used in this study, a separate CE marked product for diagnostic use, 1928DSA*, is also offered on the website for antibiotic resistance determination of S. aureus.