2019-04-11

Outbreak Analysis Using 1928 - Klebsiella pneumoniae

cgMLST UPGMA-clustering of a Klebsiella pneumoniae outbreak using the 1928 platform

The tree is created using UPGMA and distances shown are computed based on pairwise allelic differences (hamming distance). Missing genes are not included in the count.

1928's analysis of an outbreak: Klebsiella pneumoniae

The ambition with 1928’s outbreak analyses is to reproduce results from scientific studies and highlight the quality of the results generated by the 1928 platform.

In order to demonstrate the accuracy of outbreak analysis with the 1928 platform, a phylogenetic tree is created from an outbreak of Klebsiella pneumoniae. The tree shown in the figure above is generated using the 1928 analysis platform.

In this analysis, 1928 reproduces results from the scientific paper Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae at a single institution: insights into endemicity from whole-genome sequencing (pmid: 25561339) by Mathers AJ et.al.

The 1928 Klebsiella pneumoniae cgMLST schema is created from 270 reference genomes giving the scheme 3459 core genes. All genes included in the schema are present in at least 95% of reference genomes.